Secretly told through the perspective of a seeing-eye dog, Lola and I is a story of a friendship with a rocky start.
Lola, the human, was blinded in a car accident. She moves to the city with her seeing-eye dog, Star. Star describes Lola's pains and struggles as she adjusts to her new condition. Eventually with Star's help, Lola is able to find joy in her day-to-day life and her friendship with Star grows.